![]() CM I can be a challenging condition for patients and physicians, during both the search for diagnosis and management of symptoms. Fear was the most frequent emotion elicited at the time of correct diagnosis (42.19 %). Common misdiagnoses were classified as psychological (19.26 %) and neurological (19.26 %). CM I diagnosis was found incidentally for 24.87 % of participants. ![]() Average time to diagnosis from first physician visit to diagnosis was 3.43 years, and only 8.46 % of patients had previous awareness of CM. Neurocognitive comorbidities included memory difficulties (43.88 %) and aphasia (43.75 %) and psychological disorders such as depression (31.77 %) and anxiety disorders (19.92 %) were reported. Pain was the most frequently reported symptom (76.69 %) experienced prior to diagnosis with headaches implicated most often (73.44 %). Participants were 768 individuals with CM I and were predominantly female (86.8 %) and Caucasian (93.8 %) with an average age of 35 years. Analyses included descriptive statistics to study body system impact and patient diagnostic experiences. The current research is one component of a large investigation designed to collect information from individuals with CM through the online Conquer Chiari Patient Registry questionnaire. This study reports from the only national, online patient registry available, the symptoms, comorbid neurocognitive and psychological conditions, and diagnostic experiences of patients living with CM type I (CM I). All rights reserved.Chiari malformation (CM) is a condition in which cerebellar tonsillar ectopia may manifest with various clinical presentations. ![]() Independent testing showed that psychological factors, such as depression and anxiety, were significant negative predictors, indicating that presurgical screening and treatment for these psychological conditions may improve outcomes.Ĭhiari malformation type I Patient-reported outcomes Posterior fossa decompression Symptom improvement.Ĭopyright © 2022 Elsevier Inc. Having a family member diagnosed with CMI contributed the largest unique variance to the model, suggesting that hereditary CMI may represent a unique subset of patients with poorer outcomes. The regression model accounted for more than a third of the surgical impact variance. The regression model produced an R 2 = 0.346 and identified 5 factors with significant unique variance. Depression showed the highest correlation (r = 0.36 P < 0.00001) with a negative outcome. ![]() The factors were tested independently to identify those that were either significantly different in terms of, or significantly related to, patient-reported surgical impact on symptoms (P 2 years, multiple surgeries, symptom severity, depression, anxiety, stress, and loneliness. Sixty-five presurgical factors were selected from the self-report history questionnaires (12 variables, N = 653), standardized scales (14 variables, N = 494-581), and morphometric measurements from magnetic resonance imaging (39 variables, N = 137) data of adult women in the Chiari1000 dataset. The goal of this study was to assess if a broad array of factors is predictive of patient-reported surgical impact on symptoms.
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